High throughput protein-protein interface design(circa 2015)- [Related work done by others]


High throughput design of protein-protein interactions is now a reality thanks to work by Aaron Chevalier, Chris Bahl and others. Design begins with an antibody identified binding site. Then hotspots or binding site motifs are copied over to a library of de-novo design protein scaffold. The library of designs is expressed on a chip and tested via high-throughput screening. Using this technique it is possible to design therapeutic protein-protein binding proteins quickly, however, the vast majority of proteins are non-functional so ongoing work seeks to improve reliability.