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Responsive cells – My proposed lab’s experimental aims


Engineering responsive cells will require design of novel proteins for localization, sensing, control, products, and delivery mechanisms. The possible applications for this technology are enormous. Digestive health could be improved by a Lactococcus lactis or Lactobacillus that can respond to C. Diff or digest allergy triggers. Alzheimers could be cured by a Leukocyte modified to promote crossing the blood-brain barrier and when across releasing a protein that binds A-beta. Salmonella designed to bind selectively to tumor cells with release a localized toxin could treat cancer. In plants a responsive cell could cure uncurable viral diseases or mitigate the anti-GMO movement by producing protein toxins on-demand.

My first two aims are cellular localization and a sensing system that works both in a cell and across a membrane.